Vol 5, No 1 (2018) > Articles >

Potency of (Poly) Acrylic/Carboxymethyl Starch-Chitosan Biohydrogel for Curcumin Oral Delivery Matrix

Eka Ruriani , Djumali Mangunwidjaja , Nur Richana , Titi Candra Sunarti



Objective: Biohydrogel has gathered great interest in the pharmaceuticals field. This natural polymers were biodegradable, non-toxic, biocompatible, and its specific ability to response environment change can be considered for the controlled released matric of bioactive compound. In this study, the biohydrogel was synthesized by graft-copolymerization of acrylic acid onto carboxymethyl starch (CMS) and chitosan. The objective of this research was to determine the effect of CMS-chitosan ratio on the biohydrogel characteristic. Methods: The acrylic acid was grafted on to the backbone (3:1) by using cerric ammonium nitrate as the inisiator. A standarded curcumin was applied to test the binding potency of matrix. Results: A higher CMS ratio in the polymer mixture (4:1) revealed the highest swelling power (16.9 w/w) and percentage of curcumin absorption (17.34%). All the samples have the pH-responsive swelling properties, with the swelling trend was observed in the order of distilled water > HCl solution > phospathe buffer solution. FTIR spectra and SEM micrographs has confirmed the graft-copolymerization of PAA/CMSCs biohydrogel by describing the appearance of peak around 1600 cm-1 and the morphology of granula structure, respectively. Conclusion: The graft-copolymerization of acrylic acid onto the two anionic natural polymer by cerric ammonium nitrate as the initiator has resulted a pH-dependent swelling biohydrogel, and it has the ability to deliver curcumin in stomach-targeted system.

Keywords: acrylic acid; biohydrogel; carboxymethyl starch; chitosan; curcumin

Published at: Vol 5, No 1 (2018) pages: 25-31

DOI: 10.7454/psr.v5i1.4067

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Abdel-Halim ES, Al-Deyab SS. (2014). Preparation of poly (acrylic)/starch hydrogel and its application for cadmium ion removal from aqueous solutions. Reactive and Functional Polymers, 75, 1-8.

Ahmed EM. (2015). Hydrogel: preparation, characterization, and applications: a review. Journal of Advanced Research, 6(2), 105-121.

Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB. (2010). Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavalibility in vivo. Biochemical Pharmacology, 79, 330-338.

Athawale VD, Rathi SC. (1999). Graft polymerization: starch as a model substrate. Journal of Macromolecur Science Reviews in Macromolecular Chemistry & Physics, 39 (3), 445-480.

Bhatia JK, Kaith BS, Kalia S. (2013). Polysaccharide hydrogels: synthesis, characterization, and applications. In: Kalia S, Sabaa MW, editors. Polysaccharide Based Graft Copolymers. Berlin: Springer. p. 271-290.

Das D, Jha S, Kumar JK. (2015). Effect of carboxymethylation on physicochemical and release characteristics of Indian Palo Starch. International Journal of Biological Macromolecules, 77, 181-187.

El-Hag Ali A, Al-Arifi A. (2009) Characterization and in vitro evaluation of starch based hydrogel as carriers for colon spesific drug delivery system. Carbohydrate Polymers, 78, 725-730.

George M, Abraham TE. (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan – a review. Journal of Controlled Release, 114, 1-14.

Grabovac V, Guggi D, Bernkop-Schnurch A.. (2005) Comparison of the mucoadhesive properties of various polymers. Advanced Drug Delivery Reviews, 57(11), 1713-1723.

Herdini Darusman LK, Sugita P. (2010). Disolusi mikroenkapsulasi kurkumin tersalut gel kitosan-alginat-glutaraldehida. Makara Sains, 14(1), 57-62.

[ISO] International Organization for Standardization. (1998). Method of Carboxymethyl Starch by Titration (ISO 11216–1998) (Geneva: Intenational Organization for Standardization).

Jaspreet S, Lovedeep K, Mccarthy OJ. (2007) Factors influencing the physico-chemical, morphological, thermal and rheological properties of some chemically modified starches for food applications-a review. Food Hydrocoll, 21, 1-22.

Jyothi AN, Carvalho AJF. (2013). Starch-g-copolymers: synthesis, properties and applications. In: Kalia S, Sabaa MW, editors. Polysaccharide Based Graft Copolymers. Berlin: Springer. p. 59-109.

Kunnumakkara AB, Anand P, Aggarwal BB. (2008). Curcumin inhibit proliferation, invasion, angiogenesis and metastatis of different cancers through interaction with multiple cell signaling proteins. Cancer Letters, 269, 199-225.

Lawal OS, Lechner MD, Kulicke WM. (2008). Single and multistep carboxymethylation of water yam (Dioscorea alata) starch: synthesis and characterization. International Journal of Biological Macromolecules, 42, 429-435.

Lazim AM, Mokhtar F, Yusof SFMA, Ahmad I, Hakam A. (2013). Synthesis and characterization of ph sensitive hydrogel using extracted pectin from dragon fruit peel. Malaysian Journal of Analytical Sciences, 17(3), 481-489.

Letchford K, Liggins R, Burt H. (2008). Solubilization of hydrophobic drugs by methoxy poly (ethylene glycol)-block-polycaprolactone diblock copolymer micelles; theoritical and experimental data and correlations. Journal Pharmaceutical Sciences, 97(3), 1179-1190.

Lee JW, Kim SY, Kim SS, Lee YM, Lee KH, Kim SJ. (1999). Synthesis and characteristics of interpenetrating polymer network hydrogel composed of chitosan and poly(acrylic). Journal of Applied Polymer Sciences, 73, 113-120.

Li JY, Yeh AI. (2001) Relationship between thermal, rheological characteristics, and swelling power for various starches. Journal of Food Engineering, 50, 141-148.

Nattapulwat N, Purkkao N, Suwithayapan O. (2008) Evaluation of native and carboxymethyl yam (Dioscorea esculenta) starches as tablet disintegrants. Silpakorn University Sciences and Technology Journal, 2(2): 18-25.

Pal S, Das R. (2013). Polysaccharide-Based Graft Copolymers for Biomedical Applications. In: Kalia S, Sabaa MW, editors. Polysaccharide Based Graft Copolymers. Berlin: Springer; p. 325-345.

Qiu Y, Park K. (2012). Environment-sensitive hidrogels for drug delivery. Advanced Drug Delivery Reviews, 64 (Supplement), 49-60.

Roja G, Floores JA, Rodriguez A, Ly M, Maldonado H. (2005) Adsorption of chromium onto cross-linked chitosan. Separation and Purification Technology, 44, 31-36.

Saboktakin MR, Tabatabaie, Maharramov RM, Ramazanov MA. (2010). Synthesis and characterization of chitosan-carboxymethyl starch hidrogels as nano carriers for colon-specific drug delivery. Journal of Pharmaceutical Education and Research, 1(2), 37-47.

Sangseethong K, Chatakanonda P, Wansuksri R, Sriroth K. (2015). Influence of reaction parameter on carboxymethylation of rice starches with varying amylose contents. Carbohydrate Polymers, 115, 186-192.

Sangseethong K, Ketship S, Sriroth K. (2005). The role of reaction parameter on the preparation and properties of carboxymethyl cassava starch. Starch, 57, 84-93.

Shi H, Hu X. (2013). Preparation and structure characterization of carboxymethyl corn starch under ultrasonic irradiation. Cereal Chemistry, 90(1), 24-28.

Spychaj T, Zdanowicz M, Kujawa J, Schmidt B. (2013). Medium and high substituted carboxymethyl synthesis, characterization and application. Starch/Stärke, 65, 22-23.

Tokarev I, Minko S. (2010). Stimuli-responsive porous hidrogels at interfaces for molecular filtration, separation controlled release, and gating in capsules and membranes. Advanced Materials, 22(31), 3446-3462.

Tripathi R, Mishra B. (2012). Development and evaluation of sodium alginate–polyacrylamide graft–co-polymer-based stomach targeted hydrogels of famotidine. AAPS Pharm Sci Tech, 13(4), 1091-1102.

Wang Q, Zhang J, Wang A. (2009) Preparation and characterization of a novel pH-sensitive chitosan-g-poly (acrylic acid/attapulgite/sodium alginate) composite hydrogel bead for controlled release of diclofenac sodium. Carbohydrate Polymers, 78. 731-737.

Wilken R, Veena MS, Wang MB, Srivatsan ES. (2011). Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Molecular Cancer, 10(12), 1-19.

Yao KD, Peng T, Feng HB, He YY. (1994) Swelling kinetics and release characteristic of crosslinked chitosan polyethe-polymer network (semi IPN) hydrogels. Journal of Polymer Science, A: Polymer Chemistry, 32, 1213-1223.

Zhang B, Li H, Li X, Cheng C. (2015). Preparation, characterization, and in vitro release of carboxymethyl starch/β-cyclodextrin microgel-ascorbic acid inclusion complexes. RSV Adv, 5, 61815-61820.

Zhang Z, Zhang R, Zou L, Chen L, Ahmed Y, Al-Bishri W, Balamash K, Julian D. (2016). Encapsulation of curcumin in polysaccharide-based hydrogel beads: impact of bead type on lipid digestion and curcumin bioaccessibility. Food Hydrocol 2016, 58, 160-170.

Zohuriaan-Mehr MJ, Kabiri K. (2008). Superabsorbent polymer materials: a review. Iranian Polymer Journal, 17(6), 451.