Vol 2, No 2 (2005) > Articles >

PENGARUH PEMBERIAN EKSTRAK BIJI KLABET (TRIGONELLA FOENUM-GRAECUM L.) TERHADAP KADAR HORMON ESTRADIOL DAN FSH PLASMA TIKUS PUTIH BETINA GALUR WISTAR PREPUBERTAL

Kurnia Agustini , Sumali Wiryowidagdo , Dadang Kusmana

 

Abstract: Biji Klabet or Fenugreek (Trigonella foenum-graecum L.) contains steroidal sapogenins such as diosgenin, tigogenin, gitogenin, yamogenin and trigoneoside, that are suspected having an estrogen-like effect or as phytoestrogen. The objective of this study was to evaluate the estrogen-like effect of biji klabet alcohol extracts. This research used immature Wistar female rats, age of 19 days, which were represent the climacteric/menopause phase. The testing animals were divided into five groups, namely normal group, estradiol control group and three level dose groups of fenugreek extract (30 mg/200 gBW; 60 mg/200 gBW and 120 mg/200 gBW). The result showed that on 120 mg/200 gBW fenugreek extract significantly (a=0.05) increased estradiol and FSH level on immature rat. Analysis of vaginal smear showed vaginal lubrication effect, surprisingly on 120 mg/200 gBW could induce estrous cycle.

Keywords: biji klabet; estrogen-like effect; phytoestrogen; Trigonella foenum-graecum L.

Published at: Vol 2, No 2 (2005) pages: 74-83

DOI: 10.7454/psr.v2i2.3820


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