Vol 4, No 3 (2007) > Articles >


Ilma Nugrahani , Sukmadjaja Asyarie , Sundani N.S. , Slamet Ibrahim


Abstract: Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.

Keywords: amoxicillin trihydrate - potassium clavulanate; physical chemical interaction; solution calorimetry; cool contact methods; amoksisilina trihidrat - kalium klavulanat; interaksi kimia fisika; kalorimetri larutan; metode kontak dingin

Published at: Vol 4, No 3 (2007) pages: 93-99

DOI: 10.7454/psr.v4i3.3803

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