Vol 7, No 3 (2010) > Articles >

Pengaruh Kombinasi Hidroksipropil Metilselulosa-Xanthan Gum sebagai Matriks Pada Profil Pelepasan Tablet Teofilin Lepas Terkendali

. Iskandarsyah , . Sutriyo , Dian Hayati

 

Abstract: Theophylline is a bronchodilator used for the treatment of bronchial asthma and other
respiratory diseases. Theophylline has a narrow therapeutic index (10-20 µg/ml) and
relatively short elimination half-life (6,19 ± 0,031 hours). Causes rapid elimination
rate of theophylline should be given periodically to maintain drug levels in blood for
the desired therapeutic effect can be achieved. The preparation of theophylline controlled
release is expected to produce blood concentrations of theophylline in a more
stable.
The physical properties of tablets and drug release from matrix systems are influenced
by the nature of the composition of the matrix. This research, theophylline controlled
release tablets were made by combination of xanthan gum and HPMC as matrix
composition. Combination of HPMC and xanthan gum was supposed to produce
tablets with the required pysical properties and ability to extend the releasing period of
theophylline from matrix system. HPMC-xanthan gum compositions used in formulation
were 1:4, 1:1, and 4:1.
Based on the evaluation of the physical properties carried out on the tablet, it was
found out that the three formulas fit the requirements for ideal tablet. The increasing
of xanthan gum concentration in the formula was proportional with the improvement
of mass flowability and tablet hardness. Evaluation of the releasing profile of
theophylline from matrix system had been conducted in vitro by dissolution test.
Based on the test, it was found out that all combinations have variation in releasing
profile. The increasing of HPMC concentration in formula will extend the releasing
time of theophylline. The difference in releasing profile of Retaphyl SR® with formula
1, 2, and 3 because of differences in raw materials that form the matrix.
Key words: hydroxypropyl methylcellulose, controlled released tablet, theophylline,
dissolution testing, and xanthan gum.

Published at: Vol 7, No 3 (2010) pages: 58-70

DOI: 10.7454/psr.v7i3.3461


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