Vol 7, No 3 (2010) > Articles >

Eksipien Koproses Pregelatinisasi Pati Singkong Metilselulosa sebagai Bahan Penyalut Tablet

Rangga Pradana , Effionora Anwar , . Chaidir

 

Abstract:

Coating is one of the effective methods used in controlled release dosage form. Lots of
variety in the form of a hydrophilic polymer excipient that is used to control the drug
release many polymers that can be used for coating purposes, but only a few have been
known to serve as a polymeric coating which functions to control the rate of drug
release Pregelatinized cassava starch (PCS) is a physically modified starch. The purposes
of the study were to improve functionality of PCS with making coprocess composed
of PCS and methylcellulose (MC) by proportionally variation, which are 2:1,
3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug
release as coating material of theophylline tablet. Coprocessed excipient characterized
in terms of morphology, particle size distribution, compressibility index, flow rate
and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and
moiety analysis.


Keywords : co-prosses, pregelatinized cassava starch, methylcellulose.


Published at: Vol 7, No 3 (2010) pages: 1-15

DOI: 10.7454/psr.v7i3.3457


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