Vol 7, No 2 (2010) > Articles >

Preparasi dan Karakterisasi Nanosuspensi dengan Polivinilpirolidon (PVP) Sebagai Pembawa Nanopartikel Senyawa Asam Mefenamat

Iskandarsyah Iskandarsyah , Alip Mutakim

 

Abstract:

Several methods and technologies to increasing the solubility and dissolution rate of a
drug substance has been successfully developed, such as forming of a complexing
compound, salt preparation, adjusting the pH, making of solid dispersions, etc. One
of the technologies that are being developed is nanoparticle technology. Micronization
of drug that is processed to produce particles with nano-size. This research aims to
create and characterize nanosuspension with Polyvinylpyrrolidone (PVP) as the
vehicle of mefenamic acid nanoparticles using vibrating mill and ultrasound equipment.
Nanosuspension obtained was characterized by optical microscope and PSA to
perform optimization nanosuspension formed. The result of characterization showed
that the nanosuspension have an average diameter is 623.9 nm. Then, nanosuspension
of mefenamic acid was freeze drying. Nanosuspension and bulk of mefenamic acid
were characterization by XRD and put in a hard capsule shell for dissolution test.
Profile of dissolution test with tris buffer media indicates that nanosuspension of
mefenamic acid has a pattern of drug release is slower and constant compared with the
mefenamic acid. bulk.


Keywords: Mefenamic acid, Polyvinylpyrrolidone, Nanosuspension, freeze dyer,
Dissolution profile test.


Published at: Vol 7, No 2 (2010) pages: 52-61

DOI: 10.7454/psr.v7i2.3456


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