Vol 7, No 2 (2010) > Articles >

Eksplorasi dan Karakterisasi berbagai Kristal Ibuprofen

Arry Yanuar , Nursanti Nursanti , Effionora Anwar

 

Abstract:

Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofen
have a bad flowability because a high cohesivity. Another problem in manufacturing
is the high tendency for sticking to the punches. Besides these disadvantageous properties,
ibuprofen indicates bad dissolution behavior because of its hydrophobic structure.
To improve the properties of ibuprofen can be used crystallization method with
using variation of solvents. In this experiment observed crystallization method by
cooling, evaporation, and water presence, which used methanol, ethanol, and acetone
solvents. Of all the crystallization results are produced white prism-shaped crystalline.
The selected method is cooling method, which is characterized using Scanning
Electron Microscopy (SEM), powder X-ray diffraction, and Differential Scanning
Calorimetry (DSC). These three characterizations indicate transformation of crystal
form which compared with ibuprofen’s standard. The selected method also produces
non cohesive powder which have the size particle is 710-1180µm, compressibility
index: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º,
IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’s
solubility. The result indicates that crystallization method is able to improve flowrate,
compressibility index, and dissolution rate properties of ibuprofen’s standard.

Keywords : Ibuprofen, Crystal habit, Polymorphism, Crystallization techniques.


Published at: Vol 7, No 2 (2010) pages: 43-51

DOI: 10.7454/psr.v7i2.3455


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