Vol 7, No 2 (2010) > Articles >

Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering

Ilma Nugrahani , Sukmadjaja Asyarie , Sundani Soewandhi , Slamet Ibrahim

 

Abstract:

The polymorphismof amoxicillin has been identified after freeze drying process. The
freeze dried amoxicillin have some specific physical properties different from their raw
material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve
from DSC thermogram changes to endothermal curve, diffractogram XRD changes to
different profile, and the crystal shows different habit. All of data showed that freeze
drying process improve amoxicillin to different crystal form which has higher melting
oxidation point and lower hydrate. The improvement of the crystal structure might
be impact to change physical-pharmaceutical properties like dissolution, absorption,
and change it antibiotic potency.


Keywords: amoxicillin trihydrate, freeze drying, polymorphism.


Published at: Vol 7, No 2 (2010) pages: 10-15

DOI: 10.7454/psr.v7i2.3452


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