Vol 7, No 2 (2010) > Articles >

Pengaruh Ac-Di –Sol Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam dengan Metode Cetak Langsung

Dwi Setyawan , Bambang Widjaja , Indah Sayekti



Orally Disintegrating Tablet (ODT) or Fast Release Tablet is solid dosage form which
disintegrated rapidly in mouth and its residue easy to swallowed. This research observed
the influence of Ac-Di-Sol concentration as disintegrant on physical characteristics
and dissolution rate of piroxicam orally disintegrating tablet which were
prepared by direct compression. Ac-Di-Sol was used in concentration of 1%, 3% and
5%, and 0% as control. The powder blend was pressed into tablet by hydraulic press
with a pressure of 1 ton and diameter of 8 mm and its hardness, friability, disintegration
time and dissolution rate were examined. The results showed that the increasing
of Ac-Di-Sol concentration would increase hardness, disintegration time, dissolution
rate and decrease friability of the tablet. From statistical analysis (µ =0,05), it was
showed that there was significant difference among formulas on the hardness, friability,
disintegration time and dissolution rate. The hardness of piroxicam Orally Disintegrating
Tablet of all formulas were between 0.99 - 2.77 kP, friability were between
3.45 – 1.35%, disintegration time were between 223.67 – 20,0 sec and drug released
at 45 minutes were between 32.71 – 96.25%. From this research, it could be concluded
that formula with 3% concentration of Ac- Di-Sol give the most desirable
output, even though there was a problem with the friability.

Keywords : Orally disintegrating tablet, piroxicam, Ac-Di-Sol, direct compression,
physical characteristics, dissolution rate.

Published at: Vol 7, No 2 (2010) pages: 1-9

DOI: 10.7454/psr.v7i2.3451

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