Vol 7, No 1 (2010) > Articles >

Uji Efek Antiartritis Ekstrak Etanol 80% Kulit Buah Delima Merah (Punica granatum L) Terhadap Udem Pada Telapak Kaki Tikus Putih Jantan yang diinduksi oleh Complete Freund’s Adjuvant

Rusmalita Sari , Juheini Amin , Santi Sari


Abstract: Rheumatoid arthritis is a chronic inflammatory disease that can degrade the quality
of patient survival. Conventional treatments of this disease have potentially dangerous
side effects. Therefore, many patients are turning to alternative medicine using
medicinal herbs, one of which is the fruit of Punica granatum L. The aim of this
research was to determine antiarthritis effect of 80% ethanolic extract of Punica granatum
L. fruit peel which had been given orally on 17-30th day based on decreased edema
volume and percentage indexes of arthritis. The method was adjuvant induced arthritis
by using the complete freund’s adjuvant 0,1 mL by subplantar and allowed to
arthritis until day 16. The animals test were used 33 male rats of Sprague Dawley
strain that were divided into six groups: normal control, positive control, negative
control, and three groups had received suspension of 80% ethanolic extract of Punica
granatum L. fruit peel in 0,5% CMC at doses 20, 40, and 80 mg/200 g body weight.
The Edema volume was measured by pletismometer on days 17, 20, 23, 26, 29, 31
and indexes of arthritis determined on days 17 and 31. The Results showed that they
were not significant difference in the decreased edema volume and the percentage
indexes of arthritis, although the percentage inhibition of edema elevated with increasing

Published at: Vol 7, No 1 (2010) pages: 34-48

DOI: 10.7454/psr.v7i1.3449

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