Vol 7, No 1 (2010) > Articles >

Pengaruh Avicel PH 102 Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam Dengan Metode Cetak Langsung

Dwi Setyawan , Bambang Widjaja , Zimy Ningtyas

 

Abstract: The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolution
rate of piroxicam Orally Disintegrating Tablet prepared by direct compression
method was observed in this research. Concentration of Avicel PH 102 used were 5%,
10%, 15% and 0% as a control. Physical characteristics of the powder blend including
flow rate and angle of repose showed good attributes. The powder blend was pressed
into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. The
physical characteristic of piroxicam orally disintegrating tablet including hardness,
friability, disintegration time, and dissolution rate were examined. The hardness of
all formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%,
disintegration time were between 223,67– 18,33 sec and drug released at 45 minutes
were between 32,71%– 88,63%. The results showed that increasing the concentration
of Avicel PH 102 would increase the hardness, and dissolution rate and decrease the
friability and disintegration time of piroxicam orally disintegrating tablet . From
statistical analysis (µ = 0,05), it could be seen that there was significant difference in
physical characteristics and dissolution rate of all formulas. Among all formulas, it
could be concluded that formula with 10% concentration of Avicel PH 102 was the
optimum formula
Keywords : Orally disintegrating tablet piroxicam, Avicel PH 102, direct compression,
physical characteristics, dissolution rate.


Published at: Vol 7, No 1 (2010) pages: 9-16

DOI: 10.7454/psr.v7i1.3446


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