Vol 5, No 2 (2008) > Articles >


Fadlina Saputri , Santi Sari , Abdul Munim


Abstract: Scientific evaluation on pharmacological activity of medicinal herbs required repro-ducible and valid method-induced ulcer models in animal. In this study, the method
of antiulcerogenic effect was investigated using several inducers. The male white Sprague-Dawley rats divided into five groups which were orally administrated water,
indomethacin (48 mg/kg bw), aspirin-HCl (150 mg/kg bw), 96% ethanol (1 ml/200 g bw), and 80% ethanol (1 ml/200 g bw), respectively. The result of this study showed that the group was induced with 80% ethanol demonstrated the highest ulcer
index. Histological examination of the stomach showed abnormality of mucosa cells on the aspirin-HCl, 96% ethanol, and 80% ethanol-induced gastric ulcer model in rats.
Key words : gastric ulcer, induction method.

Published at: Vol 5, No 2 (2008) pages: 84-90

DOI: 10.7454/psr.v5i2.3422

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