Vol 9, No 2 (2012) > Articles >

Uji Efek Analgesik Ekstrak Etanol Mencit Jantan dengan Metode Tail-Flick

. Widiarti , Retnosari Andrajati , Juheini Amin

 

Abstract:

In the previous study the analgesic effect of Cinnamommum zeylanicum Breyn had been

investigating. The aim of this study was to investigate analgesic effect of the 70% ethanol

extract of cinnamon bark (Cinnamommum zeylanicum Breyn.). This study used Tail-

Flick method at 25 male mice which have passed sensitivity test, divided into five groupes.

Group I as negative control was administered 0,5% CMC, group Il as positive control was

administered tramadol HCI, group Ill, IV and V was administered extract of cinnamon

bark at 8; 16 and 32 mg/20 g BW. Drugs were orally administered to mice. The reaction of

time exhibited by each animal was counted for two hour with interval thirty minutes. The

Result revealed that the prepared extract in at the all dose, had analgesic effect significantly

in all groups which have been studied (p< 0,05) in comparison to the negative control, to

the highest analgesic effect by dose (32 mg/ 20 g BW). Our results showed that the analgesic

effect of extract (32 mg/20 g BW) the same with tramadol hidroclorida.

Keywords: Analgesic; Cinnamommum zeylanicum Breyn.; Kayu manis; Tail- Flick method


Published at: Vol 9, No 2 (2012) pages: 87-96

DOI: 10.7454/psr.v9i2.3355


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