Vol 1, No 2 (2014) > Articles >

Aktivitas Penghentian Pendarahan Luar Ekstrak Etanol Daun Berenuk (Crescentia cujete L) Secara In-Vivo

Anjar Mahardian Kusuma , Adri Nurrakhmat Sulistyo , Susanti Susanti , Sabikis Sabikis



Crescenti cujete L. or better known as calabash is a plant that thrives in Indonesia. Calabash has a great potential as an herbal remedy, but there is only some scientific research conducted on this plant, one of which is antibacterial against Bacillus subtilis and Escerichia coli on 2006 by Susanti. The method in this research was an experimental activities of the cessation external bleeding with 3 dose variation of calabash leaf extract 80%, 60%, and 40% by counting the bleeding time at base of the tail in mice. As a result, all groups of external bleeding cessation activities have better outcomes than negative controls (p <0,05).

Keywords: Crescentia cujete. L, ethanol extract, external bleeding

Published at: Vol 1, No 2 (2014) pages: 134-140

DOI: 10.7454/psr.v1i2.3299

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Ejelonu, B.C., Lasisi, A.A.,Olaremu, A.G., and Ejelonu, O.C. (2011). The chemical constituents of calabash (Crescentia cujete). African Journal of Biotechnology, 10 (84), 19631-19636.

Kaneko, T., Ohtani, K., Kasai, R., Yamasaki, K., Duc, N.M. (1998).n-Alkyl glycosides and p-hydroxybenzoyloxy glucose from fruits of Crescentia cujete. Phytochemistry, 47, 259–263.

Kee, J. L., dan Evelyn, R. H. (1996). Farmakologi : Pendekatan proses Keperawatan. Cetakan I. Jakarta: Penerbit Buku Kedokteran EGC.

Lim, T.K. (2012). Edible Medicinal and Non-Medicinal Plants. Volume 1 Fruits. London: Springer

Mahbub, K. R., Hoq, M. M., Ahmed, M. M., & Sarker, A. (2011). In vitro antibacterial activity of Crescentia cujete and Moringa oleifera. Bangladesh Research Publications Journal, 5(4), 337-43.

Mansjoer, A. M., dkk. (1999). Kapita Selekta Kedokteran, Jakarta: media ausculapius FKUI.

Marc, N.O. (2008).The Nutritive and Anti-nutritive Compositions of Calabash Crescentia cujete. Journal of Food Technology, 6, 267-270.

Murch, S. J., Liu, C., Romero, R. M., Saxena, P. K. (2004). In vitro culture and temporary immersion bioreactor production of Crescentia cujete. Plant Cell Tiss. Organ Cult. 78, 63–68

Pharmacophee Caribeenne. (1999). Pharmacophee Caribeenne, lionel germosenrobineou . Editor Santo Domingo, tramil; Hlm : 161

Rojas, G., Levaro, J., Tortoriello, J., Navarro, V. (2001). Antimicrobial evaluation of certain plants used in Mexican traditional medicine for the treatment of respiratory diseases. Journal of Ethnopharmacology, 74, 97-101.

Salawu, O., Aliyu, M., Tijani, A.Y. (2008). Haematological studies on the ethanolic stem bark extract of Pterocarpus erinaceus poir (fabaceae). African Journal of Biotechnology, 7(9), 1212-1215.

Sundaram, C. P., and Keenan, A. C. (2010). Evolution of hemostatic agents in surgical practice. Indian Journal of Urology, 26(3), 374 – 378

Susanti. (2008). Aktivitas Antibakteri Ekstrak Air dan Etanol Daun Berenuk (Crescentia cujete L). Pharmacy, 4(3), 177-183