Vol 1, No 1 (2014) > Articles >

Pengaruh Natrium Hialuronat terhadap Penetrasi Kofein Sebagai Antiselulit dalam Sediaan Hidrogel, Hidroalkoholik Gel, dan Emulsi Gel

Joshita Djajadisastra , Zuraida Syafara Dzuhro , Sutriyo Sutriyo



Anticellulite  topical   gel   preparation   with   caffeine   as   active   ingredient   needs a  penetration enhancer to reach subcutaneous layer.  Sodium hyaluronate (NaHA),   the sodium salt of hyaluronic acid, is a hydrophilic  polysaccharide  derivative  polymer. It has  ability  to  enhance  percutaneous  penetration  by  loosening  the  dense  of the compact substance stratum corneum.  The  aim  of  this  research  was  to  observe the effects of NaHA on caffeine penetration as  anticellulite  active  agent  in  three types of gel preparation: hydrogel,  hydroalcoholic  gel,  and  gel  emulsion.  Each gel type contained caffeine  1,5% and was varied into three formulas. Formula      1 contained HPMC 2% as gel basis; formula 2 contained HPMC 2% and NaHA 0,5%; formula 3 contained NaHA 2% as gel basis. Caffeine penetration properties were analyzed by Franz diffusion cell in vitro test using rat skin as membrane. Percent caffeine penetration of hydrogel formula 1, 2, 3 were 9,41 ± 0,01%; 11,74 ± 0,13%; 16,32 ± 0,03%, respectively. Percent caffeine penetration of hydroalcoholic gel formula 1, 2, 3 were 19,54 ± 0,02%; 22,99 ± 0,23%; 7,42 ± 0,08%, respectively. Percent caffeine penetration of gel emulsion formula 1, 2, 3 were 10,47 ± 0,19%; 13,41 ± 0,12%; 18,42 ± 0,06%, respectively. The result showed that NaHA enhanced the caffeine percutaneous penetration properties in various gel preparations, except hidroalkoholic gel formula 3.

Keywords: caffeine, Franz diffusion cell, hydroalcoholic gel, hydrogel, sodium yaluronate

Published at: Vol 1, No 1 (2014) pages: 46-63

DOI: 10.7454/psr.v1i1.3298

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Anggraeni, C. A. (2008). Pengaruh Bentuk Sediaan Krim, Gel, dan Salep terhadap Penetrasi Aminofilin sebagai Antiselulit secara in vitro Menggunakan Sel Difusi Franz. Skripsi. Depok: Universitas Indonesia.

Balazs, E. A., Henry, H., Riverdale, Y. N. (1981). Hyaluronate Based Compositions and Cosmetic Formulations Containing Same. Patent No. 4,303,676. United States of America

Balazs, E. A. (2004). Viscoelastic Properties of Hyaluronan and Its Therapeutic Use. Netherland: Elsevier Ltd.

Barel, A. O. (2001). Anticellulite Products and Treatments. Handbook of Cosmetics Science and Technology

Brown, M., & Jones, S. (2005). Hyaluronic Acid: A Unique Topical Vehicle for the Localized Delivery of Drugs to the Skin. Journal of the European Academy of Dermatology and Venereology, 308-318.

Brown, T. J., Alcorn, D., & Fraser, J. R. (1999). Absorption of Hyaluronan Applied to the Surface of Intact Skin. The Journal of Investigative Dermatology, 740-746.

Brum, C. (2010). Psychological Impact of Cellulite on the Affected Patients (2nd ed). New York: Informa Healthcare. (2nd ed., p. 536). New York: Marcel Dekker, Inc.

Barret, C. (1969). Skin Penetration. Journal Society Cosmetic Chemists, 20, 487-499.

Begoun, P. (2006). Bumpy Road Ahead. Washington: Paula’s Choice, Inc.

Benson, H. A. (2005). Transdermal Drug Delivery: Penetration Enhancement Techniques. Current Drug Delivery, 2, 23-33.

Bernard, I. J. L. (2008). Semipadat. Teori dan Praktek Farmasi Industri. Terj. dari The Theory and Practice of Industrial Pharmacy. (Edisi Ketiga). Jakarta: UI Press.

Forster, M., Bolzinger, M. A., Fessi, H., & Briancon, S. (2009). Topical Delivery of Cosmetics and Drugs Topical Delivery of Cosmetics and Drugs and Delivery. European Journal of Dermatology, 309-323.

Gemborys, M., & Wisniewski, S. J. (1992). Method for percutaneous delivery of ibuprofen using hydroalcoholic gel. Patent No. 5093133. Pennsylvania.

Yoshita. (1993). Farmasi Fisik. (Martin, A., Swarbrick, J., & Cammarata). Jakarta: UI Press.

Necas, J., Bartosikova, L., Brauner, P., & Kolar, J. (2008). Hyaluronic Acid (Hyaluronan): A Review. Veterinary Medicina, 397-411.

Williams, A. C., & Barry, B. W. (2007). Chemical Permeation Enhancement. In

Touitou, E. & Barry, B.W.(2006). Enhancement in Drug Delivery. New York: CRC Press.