OPTIMASI KOMBINASI KARBOPOL 940 DAN HPMC TERHADAP SIFAT FISIK GEL EKSTRAK DAN FRAKSI METANOL DAUN KESUM (Polygonum minus Huds.) DENGAN METODE SIMPLEX LATTICE DESIGNRafika Sari, Siti Nani Nurbaeti, Liza Pratiwi
Indonesia especially Kalimantan Barat well known by it’s biodiversity, one of the potential is Kesum leaves. Kesum leaves were potential by its antibacterial effect so can be formulated into medicine form especially gel. This research aims to know the best comparison between gel basis Carbopol 940 and Hidroxypropyl methylcellulose (HPMC) affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gel was form into three basis comparison such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol – 50% HPMC). According to SLD method was get the optimum combination among the basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and 10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Gel then was tested the stability of phisycal including sticking ability, spreading ability and pH. Result were analyzed using One sample t- test and was known there is no difference of the physical stability between Kesum leaves methanol extract gel and Kesum leaves methanol fraction gel.
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