Vol 3, No 2 (2016) > Articles >

Optimasi Kombinasi Karbopol 940 dan HPMC Terhadap Sifat Fisik Gel Ekstrak dan Fraksi Metanol Daun Kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design

Rafika Sari , Siti Nani Nurbaeti , Liza Pratiwi

 

Abstract:

Indonesia especially west Kalimantan well known by its biodiversity. one of the potential resource is Kesum leaves. Kesum leaves are potential as antibacterial effect, so it can be formulated into pharmaceutical dosage form, especially gel. This research aimed to know the best comparison between Carbopol 940 and Hydroxypropyl methylcellulose (HPMC) gel base affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gels were prepared into three variation base such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol – 50% HPMC). According to SLD method, the optimum combination obtained among the basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and 10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Gel that was formulated were tested their physical stability, including adhesive ability, spreadability and pH. The results were analyzed using One sample t- test and was known there was no difference of the physical stability between Kesum leaves methanol extract gel and Kesum leaves methanol fraction gel.


 


Keywords: kesum leaves, gel, simplex lattice design

Published at: Vol 3, No 2 (2016) pages: 72-79

DOI: 10.7454/psr.v3i2.3288


Access Counter: 331 views

Full PDF Download

References:

Bolton, S. (1997). Pharmaceutical Statistic Practical and Clinical Application, Third Edition, Marcel Dekker inc. New York, page 611- 619.

Ida, N. Dan Fauziah, N. (2012). Uji Stabilitas Fisik Gel Ekstrak Lidah Buaya (Aloe vera L.). Majalah Farmasi dan Farmakologi, 16(2), 79- 84.

Liebermen, H.A. (1996). Pharmaceutical Dosage Form, Vol. 2, Marcel Dekker Inc, New York, 400

Martin, A., Swabrick, J., Cammarata, A. (1993). Farmasi Fisik. UI Press. Jakarta. Halaman 1171,1172-1175.

Rowe, R.C., Sheskey, P.J., Quinn, M. (2009). Handbook of Pharmaceutical Excipients. Fifth Edition. Pharmaceutical Press and American Pharmacist Association : Washington DC. Halaman 111, 301, 794.

Sari, R. dan Isadiartuti, D. (2006). Studi Efektivitas Sediaan Gel Antiseptik Tangan Ekstrak Daun Sirih (Piper betle Linn). Indonesian J. Pharm, 17(4), 163-169.

Wibowo, M.A. (2007). Uji antimikroba fraksi metanol dan dietil eter daun tanaman kesum. Agripura, 3(2), 410-414.

Wibowo, M.A., Anwari, M.S., Aulanni’am, dan Rahman, F. (2009). Skrining Fitokimia Fraksi Metanol, Dietil- eter dan n- Heksana Ekstrak Daun Kesum (Polygonum minus Huds.). Agripura,16(4), 56-58.

Yaacob KB. (1987). Kesom oil: A natural source of aliphatic aldehydes. Perfumer and Flavorist,12, 27-30.